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Contraindicated (one)pentobarbital will decrease the extent or result of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or effect of dutasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.pentobarbital decreases amounts of amphotericin B